The Lake Tahoe Basin is a highly complex biophysical and social environment. The challenges posed by its restoration and continued management for multiple benefits are paralleled by few places in the world. Restoration and management of the Basin’s ecosystem have required the sustained engagement of federal, state, and local governments, and the private sector. Yet determining how to proceed with conservation and restoration efforts in the face of limited information remains a central challenge. The collaborative and integrated efforts of local, state, regional, and federal governments, the scientific community, and the public is ongoing.